COOK-WAITE Anesthetics: Average Durations

CARBOCAINE 3% injection
(mepivacaine hydrochloride injection, USP)
20 MINUTES infiltration
40 MINUTES inferior alveolar block

CARBOCAINE 2% with NEO-COBEFRIN 1:20,000 injection
(mepivacaine hydrochloride and levonordefrin injection, USP)
50 MINUTES infiltration
60-75 MINUTES inferior alveolar block

Lidocaine HCl 2% and Epinephrine 1:100,000 injection
(lidocaine hydrochloride and epinephrine injection, USP)
60 MINUTES infiltration
90 MINUTES inferior alveolar block

Lidocaine HCl 2% and Epinephrine 1:50,000 injection
(lidocaine hydrochloride and epinephrine injection, USP)
60 MINUTES infiltration
90 MINUTES inferior aveolar block

MARCAINE .050% with Epinephrine 1:200,000 (as bitartrate) injection
(bupivacaine hydrochloride and epinephrine injection, USP)
5-6 HOURS infiltration
5-7 HOURS inferior alveolar block

These average durations of pulpal anesthesia were determined after extensive consultations with practicing dentists and input from published literature. Variations may occur in clinical practice. Before using any of these products, please read entire prescribing information enclosed with recommendations as to patient selection, warnings, for contraindications, and adverse reactions relating to each of the products described.¹

¹ Local anesthetics should be employed only by clinicians who are well versed in diagnosis and management of dose-related toxicity and other acute emergencies which might arise from the block to be employed. Carbocaine, Carpule, Marcaine, and Neo-Cobefrin are trademarks of Sanofi Winthrop Inc.

Cook-Waite and Kodak are trademarks of Eastman Kodak Company.

References
Yagiela, John A.: Local Anesthetics; Anesthesia Progress; 1991, 38: 128-141.
Malamed, Stanley F.; Quinn, Christine L. Handbook of Local Anesthesia, 3rd Edition (St. Louis, 1990).
Teplitsky, Paul E.; Hablichek, Calvin A.; and Kushneriuk, Jeffrey S.: A
Comparison of Bupivacaine to Lidocaine with Respect to Duration in the Maxilla and Mandible, J. Canad. Dent.